Playbooks, reviewer perspectives, templates and demos.

AMNOG dossier

Map the comparator, draft the clinical benefit narrative against G-BA expectations, and source every claim back to the trial publication, label or SmPC.

NICE submission

Build a NICE company evidence submission against the reference case: ITCs pre-checked, model inputs reproducible, every assumption traceable.

HAS / G-BA response

Pull every relevant comparator readout, precedent decision and methodological objection into one workspace.

Template

Knowledgeable team Download

Payer value proposition canvas

A working canvas to map your asset's value proposition for each payer archetype — clinical, economic, organisational and patient value, on one page.

Payer objection handling

Run the value story against every objection a payer has raised against similar assets in the last 36 months — and draft the response.

Price & access simulation

Model the realistic pricing corridor given the HTA outcome you're most likely to get and the international reference pricing knock-ons.

Article

Marcus Iyengar 11 min read

Inside a NICE submission: what reviewers actually look for

NICE reviewers do not read your submission front-to-back. They triage. Here is the triage list — and the six questions an ex-ERG reviewer says they wrote in the margin of every dossier they ever read.

Guide

Knowledgeable team 14 min read

HTA submission checklist (EU5 + UK)

A practical checklist for HTA submission readiness across EU5 + UK — what each body actually checks for at clarification, and how to be ready before the question lands.

Article

Knowledgeable editors 9 min read

Reading a NICE FAD without losing the plot

How to read a NICE FAD for what it actually signals — the unspoken pushbacks, the cost-effectiveness sensitivities the committee dwells on, and the precedent it sets for your next submission.

HTA insights without the headaches: Evidence that shapes decisions

Article