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Our mission

Every team in market access is rebuilding the same knowledge, project after project. We're building the operating system that ends that. The work you did yesterday powers the work you do tomorrow.

Principles

Three things we won't compromise on.

Grounded

Every output traces back to a source. No black-box answers. Ever.

Governed

Private to your organisation. Reviewable. Audit-ready by default.

Compounding

The system gets better with every project. Knowledge accumulates instead of evaporating.

Who we are

Built by the people who do the work.

We've sat in the access seats. We've defended dossiers. We've stayed late before submissions. Knowledgeable is what we wished we had.

Health economists

Senior HEOR practitioners who've built dossiers across EU5, US, APAC and emerging markets.

Market access strategists

People who've sat across the table from G-BA, NICE, HAS and AIFA. And won.

Evidence specialists

Information scientists and evidence reviewers who designed our structured, audit-tracked review workflows.

Engineers & data scientists

ML, knowledge graph and platform engineers who've shipped production AI at scale.

The team

Team

A small, senior team of operators, scientists and engineers, every one of us has shipped, defended or built the work Knowledgeable is replacing.

Founded by Mark Byrom (Co-Founder and CEO) and Dr Max Noble (Co-Founder).

Mark Byrom, Co-Founder and CEO at Knowledgeable

Mark Byrom

Co-Founder and CEO
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Dr Max Noble, Co-Founder at Knowledgeable

Dr Max Noble

Co-Founder
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Dr Louise Street-Docherty, VP, Market Access at Knowledgeable

Dr Louise Street-Docherty

VP, Market Access
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Dr Simon Leigh, VP HEOR at Knowledgeable

Dr Simon Leigh

VP HEOR
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Charlie Brook, Chief Innovation Officer at Knowledgeable

Charlie Brook

Chief Innovation Officer
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Dr Frances Pearson, Senior Director at Knowledgeable

Dr Frances Pearson

Senior Director
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Dr Rachael Hagan, Chief Product Officer at Knowledgeable

Dr Rachael Hagan

Chief Product Officer
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James Iremonger, Head of Data Science at Knowledgeable

James Iremonger

Head of Data Science
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Paul Granby, Head of Evidence and Information Science at Knowledgeable

Paul Granby

Head of Evidence and Information Science
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Brian McStay, Director of Security at Knowledgeable

Brian McStay

Director of Security
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Russell Horn, Senior Designer at Knowledgeable

Russell Horn

Senior Designer
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Megan Stoker, Associate Consultant at Knowledgeable

Megan Stoker

Associate Consultant
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Trajectory

Where we've come from. Where we're going.

2023

Foundations laid

Ontology + evidence layer designed by HEOR and information science leads.

2024

Workflow surfaces shipped

Search Strategies, Knowledge Hubs and Evidence Collections in production with launch customers.

2025

Grounded intelligence

Ask Knowledgeable, evidence summarisation and review suggestions. All source-linked.

2026

Compounding everywhere

Cross-project learning, organisation-scoped intelligence, and continuously enriched ontology.

Want to see what we've built?

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Responsible AI · Enterprise security

Responsible AI is a founding principle.

We built Knowledgeable because the industry deserves AI that is grounded, governed and designed to align with the EU AI Act. Not a flashy demo that fails procurement.

Designed to align with the EU AI ActGDPR / UK GDPRSSO + MFA enforcedAES-256 + TLS 1.2+EU / UK data residencyNo training on your dataFull audit trail