Mark Byrom | Co-Founder and CEO | Knowledgeable

Capabilities

Evidence WorkspaceGrounded answers, every claim source-linked.HTA & Payer IntelligenceG-BA, NICE, HAS, AIFA in one cockpit.Dossier BuilderReviewer-shaped templates, defensible outputs.Compounding KnowledgeEvery project teaches the next one.

Workflows

Submission SprintAMNOG, NICE & HAS in weeks, not quarters.Investor-Ready NarrativeSeries C and BD-grade value story.Agency Mandate DeliveryJuniors at senior quality from week one.

Featured

AI you can defendGrounded, sourced, designed to align with the EU AI Act.Security & ComplianceSSO, MFA, audit log, EU residency.

What's new

QC mode for review-heavy mandates.

Flag thin sources before the senior reviewer opens the doc.

Designed to align with the EU AI Act · SSO + MFA · EU / UK residency

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Market Access & HTA

AMNOG dossierModule 4 in nine days.NICE submissionReference-case ready.HAS / G-BA responseCountry-specific, same week.Payer objectionsRebuttals drafted before the call.Price & accessStress-test the corridor.

Evidence & Medical

Rapid lit reviewTargeted reviews in hours.ITCs & MAICsReviewer-reproducible.Targeted lit reviewFocused PICO, structured, fast.Real-world evidenceRWE that lands with HTA.Med Info & SRDField-ready in 72 hours.Congress prepASCO, ESMO, ISPOR ready.

Commercial & Strategy

Launch readinessBrief that ages well.Competitive intelLive, not last quarter.Investor narrativeSeries C and BD-grade.BD & licensingAsset diligence in days.Pipeline prioritisationPortfolio calls, defensible.

Featured

From RCT to reimbursement in 14 daysThe AMNOG sprint playbook.Browse all use casesEvery job, mapped end-to-end.

Pattern of the month

AMNOG sprint playbook.

From RCT readout to G-BA-ready Module 4 in 14 days.

Designed to align with the EU AI Act · SSO + MFA · EU / UK residency

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PharmaMarket Access · HEOR · Medical Affairs

Win reimbursement. Defend the price you launched at.

By role

Market AccessWin the AMNOG window.HEORITCs and value dossiers that hold up.Medical AffairsField-ready in 72 hours.

Pharma overview

BiotechCEO · CCO · Commercial

Walk into your next round with the story already written.

By role

Clinical-stage CEOInvestor-grade narrative.Pre-launch CommercialLaunch-ready without the headcount.

Biotech overview

AgenciesPartners · Engagement Directors

3× mandates per consultant. Margin that holds at scale.

By role

Consulting PartnersFirm IP that compounds.Engagement DirectorsOn scope, on margin.

Agency overview

Designed to align with the EU AI Act · SSO + MFA · EU / UK residency

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Browse

All articlesThe full library, filterable by topic.

Latest articles

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Featured

Featured stories appear here.

GlossaryPlain-English definitions for the field.

Designed to align with the EU AI Act · SSO + MFA · EU / UK residency

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How it works

Four modesBuild, Plan, QC, Ask, one workflow.SurfacesManual, chat and copilot, same brain.RetrievalGrounded in your governed evidence.

Trust & governance

Five non-negotiablesWhat every model call must satisfy.Red linesSome lines we won't cross.InfoSec reviewThe 400-question pack, pre-answered.

Compliance

Security & ComplianceSSO, MFA, audit log, EU residency.EU AI Act alignmentRisk classification & evidence pack.Model card & lineageVersioned models, traced outputs.

Featured

AI you can defendGrounded, sourced, designed to align with the EU AI Act.Read the full AI briefModes, retrieval, trust, end to end.

What's new

EU AI Act alignment notes shipped.

Every feature classified, documented, audit-ready.

Designed to align with the EU AI Act · SSO + MFA · EU / UK residency

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Company

PrinciplesThree things we won't compromise on.Our storyBuilt by the people who do the work.TrajectoryWhere we've come from. Where we're going.

Team & culture

The teamSenior operators, scientists, engineers.Responsible AIA founding principle, not an add-on.

Trust & legal

SecuritySSO, MFA, audit log, EU residency.PrivacyDPA, sub-processors, residency.TermsMaster terms & order forms.

Featured

Meet the teamOperators who've shipped the work.Talk to the foundersDirect line, not a sales queue.

LinkedInFind us on LinkedIn

Designed to align with the EU AI Act · SSO + MFA · EU / UK residency

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